Srinivas V. Koduru, PhD, AI/ML
Director of Transcriptomics
Bioinformatics
Biomarker Discovery
Liquid Biopsies
AI/ML
Assay Development
Transcriptomics
Precision Diagnostics
NGS
Professional Summary
Visionary R&D leader with 19+ years pioneering translational research across molecular oncology, computational genomics, and precision diagnostics. Currently directing mRNA-based liquid biopsy development achieving 100% classification accuracy across 5 cancer types using AI/ML models (SVM, XGBoost, Neural Networks). Track record of 55+ peer-reviewed publications (h-index: 32, 4,284+ citations), 5 patents (4 filed 2025), and FDA 510(k) submission strategy in a CLIA/CAP-certified GMP facility. Proven ability to build and scale cross-functional teams, secure funding, and drive innovations from discovery through regulatory approval.
Core Competencies
AI/ML Classification Models
Liquid Biopsy Platforms
FDA 510(k) Strategy
NGS Bioinformatics (RNA-seq, scRNA-seq, WES)
Biomarker Discovery & Validation
CLIA/CAP & GMP (ISO 7) Operations
Clinical Trial Design
International CRO Management
Team Leadership & Mentoring
Patent Strategy & IP Portfolio
High-Throughput Automation
Multi-Omics Data Integration
Professional Experience
Director, Transcriptomics
Oct 2022 — Present
Wren Laboratories · Branford, CT
- Directing mRNA-based diagnostic development in CLIA/CAP-certified, GMP (ISO 7) facility
- Built multi-gene liquid biopsy panels achieving 100% diagnostic accuracy across 5 cancer types
- Developed AI/ML classification models (SVM, XGBoost, Neural Networks) with AUC > 0.99
- Filed 4 patents (2025) and led FDA 510(k) submission strategy
- Managed international CRO collaborations and automated high-throughput workflows
Assistant Professor
Mar 2019 — Oct 2022
Penn State College of Medicine · Hershey, PA
- Led independent research lab focused on cancer biomarker discovery using NGS
- Published 15+ peer-reviewed papers in high-impact journals
- Identified novel non-coding RNAs and extracellular vesicle signatures for early cancer detection
- Secured research funding and mentored graduate students
Research Scientist
Nov 2015 — Feb 2019
Penn State College of Medicine · Hershey, PA
- Developed computational biomarker pipelines mining TCGA, GEO, and EMBL databases
- Published in high-impact journals (Nature Medicine co-author)
- Pioneered exosome-based sRNA-seq protocols for liquid biopsy research
Associate Research Scientist
Jan 2013 — Dec 2014
Yale University · New Haven, CT
- Investigated AID enzyme mechanisms in multiple myeloma pathogenesis
- Published in Blood (journal cover article, 2012)
Postdoctoral Associate
Dec 2009 — Dec 2012
Yale University · New Haven, CT
- Characterized molecular markers in multiple myeloma bone marrow microenvironment
- Co-authored publications in Science Translational Medicine and Blood
Postdoctoral Scholar
Feb 2007 — Dec 2009
UCLA & University of Kentucky
Patents
-
Early Diagnosis of Pancreatic Cancer in Liquid Biopsies
-
Identification of Lu-PSMA Responders via Whole Blood
-
Early Diagnosis of Endometriosis in Liquid Biopsies
-
Identification of Colon Cancer Biomarkers in Whole Blood
-
Bioprinting of Human Pancreas-on-a-Chip Platform
Technologies & Platforms
Python
R
TensorFlow
scikit-learn
XGBoost
Chart.js
STAR / HISAT2
DESeq2
Seurat
CellRanger
BWA / GATK
Illumina NextSeq / MiSeq
qPCR
LIMS
FDA eSubmitter
Education
Certificate
AI & Machine Learning
VIT, India
2026
PhD
Cancer Biology, Phytomedicine
University of Fort Hare, South Africa
2007
MSc
Biotechnology
SRTM University, India
2003
BSc
Microbiology, Genetics, Chemistry
Osmania University, India
2001
Selected Publications
01
Nature Medicine
— Co-author
IF 82.9
02
Science Translational Medicine
— Co-author
IF 17.1
03
Blood
— Cover Article
IF 21.0
04
Hepatology
IF 12.9
05
Cancers
— PROSTest Liquid Biopsy (2025)
06
Journal of Cancer
— Prostate Cancer Transcriptomics (2026)
07
Stem Cells
— Adipose Stem Cell Signatures
08
Scientific Reports
— Exosome Biomarkers